Epidemiology and antimicrobial susceptibility of Gram-negative aerobic bacteria causing intra-abdominal infections during 2010–2011. (February 2015)

• Record Type: Journal Article
• Authors: Hawser, Stephen; Hoban, Daryl J.; Badal, Robert E.; Bouchillon, Samuel K.; Biedenbach, Douglas; Hackel, Meredith; Morrissey, Ian
• Is Part Of: Journal of chemotherapy. Volume 27:Number 2(2015:Apr.)
• Page Start: 67
• Page End: 73
• Publication Date: 2015-02
• Subjects: Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; 615.58
• DOI: 10.1179/1973947814Y.0000000164
• Languages: English
• ISSNs: 1120-009X

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <p>The study for monitoring antimicrobial resistance trends (SMART) surveillance program monitors the epidemiology and trends in antibiotic resistance of intra-abdominal pathogens to currently used therapies. The current report describes such trends during 2010–2011. A total of 25 746 Gram-negative clinical isolates from intra-abdominal infections were collected and classified as hospital-associated (HA) if the hospital length of stay (LOS) at the time of specimen collection was ≧48 hours, community-associated (CA) if LOS at the time of specimen collection was <48 hours, or unknown (no designation given by participating centre).</p> <p>A total of 92 different species were collected of which the most common was <italic>Escherichia coli</italic>: 39% of all isolates in North America to 55% in Africa<italic>. Klebsiella pneumoniae</italic> was the second most common pathogen: 11% of all isolates from Europe to 19% of all isolates from Asia. Isolates were from multiple intra-abdominal sources of which 32% were peritoneal fluid, 20% were intra-abdominal abscesses, and 16·5% were gall bladder infections. Isolates were further classified as HA (55% of all isolates), CA (39% of all isolates), or unknown (6% of all isolates). The most active antibiotics tested were imipenem, ertapenem, amikacin, and piperacillin–tazobactam. Resistance rates to all other antibiotics tested were high.</p> <p>Considering the current data set and high-level resistance of intra-abdominal pathogens to various antibiotics, further monitoring of the epidemiology of intra-abdominal infections and their susceptibility to antibiotics through SMART is warranted.</p> </abstract>