10p12.31-12.2 variants and risk of childhood acute lymphoblastic leukemia in a Chinese population. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Deng, Jianping; Xue, Yao; Wang, Yaping; Chen, Jing; Li, Jie; Lu, Qin; Wang, Meilin; Tong, Na; Zhang, Zhengdong; Fang, Yongjun
• Is Part Of: Leukemia & lymphoma. Volume 56:Issue 1(2015:Jan.)
• Page Start: 175
• Page End: 178
• Publication Date: 2015-01
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2014.910775
• Languages: English
• ISSNs: 1042-8194

Abstract

<abstract> <title>Abstract</title> <p>Acute lymphoblastic leukemia (ALL) is a clonal hematologic disease, and is the most common cause of childhood malignancy. Recently, a new locus was identified at 10p12.31-12.2 through a genome-wide association study (GWAS) that included racially and ethnically diverse populations. We conducted a replication study with 570 cases of ALL and 673 cancer-free controls to validated the association of this locus with ALL susceptibility in a Chinese population. The results of our study confirmed that the 10p12.31-12.2 locus was linked to childhood ALL susceptibility in the Chinese population. Interestingly, we also found that the single nucleotide polymorphisms (SNPs) in this locus had a larger effect on susceptibility to high-risk ALL than on susceptibility to low-risk ALL.</p> </abstract>