The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice. (March 2014)

• Record Type: Journal Article
• Authors: Anvari, Ebrahim; Wang, Xuan; Sandler, Stellan; Welsh, Nils
• Is Part Of: Upsala journal of medical sciences. Volume 120:Number 1(2015:Mar.)
• Page Start: 40
• Page End: 46
• Publication Date: 2014-03
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Electronic journals; 610.5
• DOI: 10.3109/03009734.2014.967422
• Languages: English
• ISSNs: 0300-9734

Abstract

<abstract> <title>Abstract</title> <p> <italic> <bold>Background.</bold> </italic> It has been proposed that the histamine 1-receptor (H1-receptor) not only promotes allergic reactions, but also modulates innate immunity and autoimmune reactions. In line with this, we have recently reported that the H1-receptor antagonist cetirizine partially counteracts cytokine-induced beta-cell signaling and destruction. Therefore, the aim of this study was to determine whether cetirizine affects diabetes in NOD mice, a model for human type 1 diabetes, and glucose intolerance in high-fat diet C57BL/6 mice, a model for human glucose intolerance.</p> <p> <italic> <bold>Methods.</bold> </italic> Female NOD mice were treated with cetirizine in the drinking water (25 mg/kg body weight) from 9 until 30 weeks of age during which precipitation of diabetes was followed. Male C57BL/6 mice were given a high-fat diet from 5 weeks of age. When the mice were 12 weeks of age cetirizine was given for 2 weeks in the drinking water. The effects of cetirizine were analyzed by blood glucose determinations, glucose tolerance tests, and insulin sensitivity tests.</p> <p> <italic> <bold>Results.</bold> </italic> Cetirizine did not affect diabetes development in NOD mice. On the other hand, cetirizine treatment for 1 week protected against high-fat diet-induced hyperglycemia. The glucose tolerance after 2 weeks of cetirizine treatment was improved in high-fat diet mice. We observed no effect of cetirizine on the insulin sensitivity of high-fat diet mice.</p> <p> <italic> <bold>Conclusion.</bold> </italic> Our results suggest a protective effect of cetirizine against high-fat diet-induced beta-cell dysfunction, but not against autoimmune beta-cell destruction.</p> </abstract>