Bariatric surgery and diabetes: Implications of type 1 versus insulin‐requiring type 2. (22nd January 2015)

• Record Type: Journal Article
• Authors: Maraka, Spyridoula; Kudva, Yogish C.; Kellogg, Todd A.; Collazo‐Clavell, Maria L.; Mundi, Manpreet S.
• Is Part Of: Obesity. Volume 23:Number 3(2015:Mar.)
• Page Start: 552
• Page End: 557
• Publication Date: 2015-01-22
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20992
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20992-sec-0001" sec-type="section"> <title>Objective</title> <p>To report the impact of bariatric surgery on metabolic outcomes in patients with type 1 diabetes (DM1) versus insulin‐requiring type 2 diabetes mellitus (IRDM2).</p> </sec> <sec id="oby20992-sec-0002" sec-type="section"> <title>Methods</title> <p>Ten subjects with DM1 were compared with 118 subjects with IRDM2 at baseline and at 1 and 2 years post‐bariatric surgery for: anthropometric measures, HbA1c, and number of medications (anti‐hyperglycemic, anti‐hypertensive, lipid‐lowering).</p> </sec> <sec id="oby20992-sec-0003" sec-type="section"> <title>Results</title> <p>DM1 and IRDM2 groups lost similar amounts of weight 2 years post‐bariatric surgery (39.5 ± 14.7 kg vs. 40.3 ± 24.4 kg). IRDM2 subjects had significant improvements in HbA1c (7.8% ± 1.4% vs. 6.8% ± 1.4%, <italic>P</italic> value <0.0001) and decreases in number of anti‐hyperglycemic (2.4 ± 0.8 vs. 0.7 ± 0.8, <italic>P</italic> value <0.0001), anti‐hypertensive (2.2 ± 1.3 vs. 1.3 ± 1.2, <italic>P</italic> value <0.0001), and lipid‐lowering (1.1 ± 0.8 vs. 0.6 ± 0.6, <italic>P</italic> value <0.0001) medications. DM1 subjects had no improvement in HbA1c (8.2% ± 1.6% vs. 7.8% ± 0.9%) or use of anti‐hypertensive medications (2.1 ± 1.4 vs. 2.3 ± 1.5). Their use of lipid‐lowering medications improved (1.0 ± 0.5 vs. 0.5 ± 0.8, <italic>P</italic> value 0.04).</p> </sec> <sec id="oby20992-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our study suggests that improved glycemic control may not be an expected outcome when considering bariatric surgery in patients with DM1; however, additional investigation is warranted.</p> </sec> </abstract>