Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study. (March 2015)

• Record Type: Journal Article
• Authors: Pownall, Henry J.; Bray, George A.; Wagenknecht, Lynne E.; Walkup, Michael P.; Heshka, Stanley; Hubbard, Van S.; Hill, James; Kahn, Steven E.; Nathan, David M.; Schwartz, Anne V.; Johnson, Karen C.; the Look AHEAD Research Group
• Is Part Of: Obesity. Volume 23:Number 3(2015:Mar.)
• Page Start: 565
• Page End: 572
• Publication Date: 2015-03
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21005
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby21005-sec-0001" sec-type="section"> <title>Objective</title> <p>To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years.</p> </sec> <sec id="oby21005-sec-0002" sec-type="section"> <title>Methods</title> <p>Body composition was measured by dual‐energy X‐ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education.</p> </sec> <sec id="oby21005-sec-0003" sec-type="section"> <title>Results</title> <p>At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post‐baseline time points.</p> </sec> <sec id="oby21005-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Reduced fat mass may place the intervention group at a lower risk of obesity‐linked sequelae, a hypothesis that can be tested by future studies of this cohort.</p> </sec> </abstract>