Log odds of positive lymph nodes as a prognostic indicator in stage IV colorectal cancer patients undergoing curative resection. Issue 4 (17th February 2015)

• Record Type: Journal Article
• Authors: Ozawa, Tsuyoshi; Ishihara, Soichiro; Sunami, Eiji; Kitayama, Joji; Watanabe, Toshiaki
• Is Part Of: Journal of surgical oncology. Volume 111:Issue 4(2015:Mar. 15)
• Page Start: 465
• Page End: 471
• Publication Date: 2015-02-17
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23855
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23855-sec-0001" sec-type="section"> <title>Background</title> <p>Recent studies have proposed the use of log odds of positive lymph nodes (LODDS) as a prognostic indicator in colorectal cancer (CRC) patients without distant synchronous metastasis. In the present study, we aimed to evaluate the prognostic impact of the LODDS in Stage IV CRC patients who have undergone curative resection.</p> </sec> <sec id="jso23855-sec-0002" sec-type="section"> <title>Methods</title> <p>We performed a retrospective review of 117 Stage IV CRC patients who underwent curative resection at our institute from 1998 to 2011. Patients were categorized into 3 groups (LODDS1–3) according to the ratio of their LODDS. The relationship between the LODDS and disease‐free survival (DFS) and overall survival (OS) rates were assessed.</p> </sec> <sec id="jso23855-sec-0003" sec-type="section"> <title>Results</title> <p>DFS was not significantly different between patients in each LODDS group. The association between the LODDS classification and OS was statistically significant (<italic>P</italic> = 0.021). Multivariate analysis indicated that LODDS classification was an independent prognostic factor for OS, with a hazard ratio of 2.95 for LODDS2 (95% confidence interval [CI]: 1.18–8.35; <italic>P</italic> = 0.021), and 2.98 for LODDS3 (95% CI: 1.20–8.37; <italic>P</italic> = 0.017).</p> </sec> <sec id="jso23855-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The LODDS is a good prognostic indicator in Stage IV CRC patients who have undergone curative resection. <italic>J. Surg. Oncol. 2015 111:465–471</italic>. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>