Chiral Recognition of Tyrosine Enantiomers Based on Decreased Resonance Scattering Signals With Silver Nanoparticles as Optical Sensor. Issue 3 (12th December 2014)

• Record Type: Journal Article
• Authors: Tan, Xuanping; Li, Qin; Shen, Yizhong; Wu, Huan; Zhao, Yanmei; Yang, Jidong
• Is Part Of: Chirality. Volume 27:Issue 3(2015)
• Page Start: 194
• Page End: 198
• Publication Date: 2014-12-12
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22410
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>A novel chiral sensing platform, employing silver nanoparticles capped with N‐acetyl‐L‐cysteine (NALC‐Ag NPs), was utilized for the discrimination of L‐tyrosine and D‐tyrosine. This nanosensor, which could be used as an optical sensing unit and chiral probe, was characterized by transmission <named-content content-type="chemicalTechnology" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">electron microscopy</named-content> (TEM) and resonance Rayleigh scattering (RRS) spectroscopy. After the proposed sensing platform interacted with L‐tyrosine and D‐tyrosine, a decreased resonance scattering signal was only obtained from L‐tyrosine. This phenomenon offered a useful assay for the selectivity and determination of L‐tyrosine with the RRS method. The linear range and detection limit of L‐tyrosine were 0.2838–20.0 µg⋅mL^‐1 and 0.0860 µg⋅mL^‐1, respectively. In addition, experimental factors such as acidity, interaction time, and the concentration of enantiomers were investigated with regard to the effect on <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">enantioselective</named-content> interaction. <italic>Chirality 27:194–198, 2015</italic>. © 2014 Wiley Periodicals, Inc.</p> </abstract>