Cover Picture: Striking Antitumor Activity of a Methinium System with Incorporated Quinoxaline Unit Obtained by Spontaneous Cyclization (ChemBioChem 4/2015). Issue 4 (2nd March 2015)

• Record Type: Journal Article
• Authors: Bříza, T.; Králová, J.; Dolenský, B.; Rimpelová, S.; Kejík, Z.; Ruml, T.; Hajdúch, M.; Džubák, P.; Mikula, I.; Martásek, P.; Poučková, P.; Král, V.
• Is Part Of: Chembiochem. Volume 16:Issue 4(2015)
• Page Start: 513
• Page End: 513
• Publication Date: 2015-03-02
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201590005
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The cover picture shows</bold> how a novel pentamethinium salt (in white) with an unforeseen expanded, conjugated quinoxaline unit directly incorporated into a pentamethinium chain localizes in mitochondria. The mitochondrial network (intensity‐based pseudocolour) of a cancer cell was visualized by this far‐red‐emitting pentamethinium salt, which exhibits high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, thus resulting in remarkable in vivo suppression of tumor growth in a nu/nu mice model with subcutaneously implanted human breast carcinoma MDA‐MB‐231. Although the mechanism of action of this first example of a methinium system with an incorporated quinoxaline unit still remains to be determined, it is a promising candidate for cancer treatment. For further details, see the paper by T. Bříza and co‐workers on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 555 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj5443vx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>