Dinuclear Copper Intermediates in Copper(I)‐Catalyzed Azide–Alkyne Cycloaddition Directly Observed by Electrospray Ionization Mass Spectrometry1. Issue 10 (22nd January 2015)

• Record Type: Journal Article
• Authors: Iacobucci, Claudio; Reale, Samantha; Gal, Jean‐François; De Angelis, Francesco
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 10(2015)
• Page Start: 3065
• Page End: 3068
• Publication Date: 2015-01-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201410301
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The mechanism of the CuAAC reaction has been investigated by electrospray ionization mass spectrometry (ESI‐MS) using a combination of the neutral reactant approach and the ion‐tagging strategy. Under these conditions, for the first time, putative dinuclear copper intermediates were fished out and characterized by ESI(+)‐MS/MS. New insight into the CuAAC reaction mechanisms is provided and a catalytic cycle is proposed.</p> </abstract>