Tuning the Excited State of Water‐Soluble IrIII‐Based DNA Intercalators that are Isostructural with [RuII(NN)2(dppz)] Light‐Switch Complexes1. (22nd January 2015)

• Record Type: Journal Article
• Authors: Stimpson, Sasha; Jenkinson, Dan R.; Sadler, Andrew; Latham, Mark; Wragg, Dr Ashley; Meijer, Anthony J. H. M.; Thomas, Jim A.
• Is Part Of: Angewandte Chemie. Volume 127:Number 10(2015)
• Page Start: 3043
• Page End: 3046
• Publication Date: 2015-01-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201411346
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The synthesis of two new Ir^III complexes which are effectively isostructural with well‐established [Ru(NN)₂(dppz)]²⁺ systems is reported (dppz=dipyridophenazine; NN=2, 2′‐bipyridyl, or 1, 10‐phenanthroline). One of these Ir^III complexes is tricationic and has a conventional N₆ coordination sphere. The second dicationic complex has a N₅C coordination sphere, incorporating a cyclometalated analogue of the dppz ligand. Both complexes show good water solubility. Experimental and computational studies show that the photoexcited states of the two complexes are very different from each other and also differ from their Ru^II analogues. Both of the complexes bind to duplex DNA with affinities that are two orders of magnitude higher than previously reported Ir(dppz)‐based systems and are comparable with Ru^II(dppz) analogues.</p> </abstract>