Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection. (December 2014)

• Record Type: Journal Article
• Authors: Nomura, Fuminori; Sugimoto, Taro; Kitagaki, Keisuke; Ito, Takashi; Kawachi, Hiroshi; Eishi, Yoshinobu; Watanabe, Ken; Igaue, Miki; Shimizu, Norio; Tomita, Makoto; Kitamura, Ken; Kishimoto, Seiji
• Is Part Of: Acta oto-laryngologica. Volume 134:Number 12(2014)
• Page Start: 1265
• Page End: 1274
• Publication Date: 2014-12
• Subjects: Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.3109/00016489.2014.944272
• Languages: English
• ISSNs: 0001-6489

Abstract

<abstract> <title>Abstract</title> <p> <italic> <bold>Conclusion:</bold> </italic> Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is considered to be a distinct entity in Japan. The combination of both HPV-DNA sequencing analysis and immunohistochemistry (IHC) for p16<sup>INK4A</sup> is useful to discriminate the OPSCC patients with a better prognosis from other cases, especially in the advanced stage. Surgical treatment is recommended for HPV-negative advanced cancer. <italic><bold>Objective:</bold></italic> The number of HPV-related OPSCCs has been increasing worldwide. However, the incidence and prognostic significance of this cancer in Japan have not yet been fully elucidated. <italic><bold>Methods:</bold></italic> Seventy-seven Japanese patients with OPSCC were enrolled in this study. The prevalence of HPV-DNA was assessed by PCR and sequencing. The expression of p16<sup>INK4A</sup> and p53 was examined by IHC. The clinicopathological parameters and disease-specific survival were analyzed for HPV-positive and -negative patients. <italic><bold>Results:</bold></italic> HPV-DNA was detected in 32 patients. Thirty-four patients were p16<sup>INK4A</sup>-positive by IHC. The patients who were positive for HPV infection were significantly younger. Furthermore, in the stage III or IV cases, the 3-year disease-specific survival of the HPV infection-positive group was significantly better than that of the HPV-negative group. Surgical treatment was demonstrated to lead to a good prognosis for the patients with HPV-negative advanced cancer.</p> </abstract>