Pharmacokinetics of peramivir after single intravenous doses in healthy Chinese subjects. (March 2015)

• Record Type: Journal Article
• Authors: Zhang, Dan; Du, Aihua; Zhang, Lina; Ma, Jingyi; Meng, Lingjie; Deng, Ming; Xu, Juan; Liu, Huichen
• Is Part Of: Xenobiotica. Volume 45:Number 3(2015:Mar.)
• Page Start: 239
• Page End: 243
• Publication Date: 2015-03
• Subjects: Metabolism -- Periodicals; Drugs -- Physiological effect -- Periodicals; Food additives -- Periodicals; Chemicals -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; Metabolism -- Periodicals; 574.133
• DOI: 10.3109/00498254.2014.960907
• Languages: English
• ISSNs: 0049-8254

Abstract

<abstract> <title>Abstract</title> <p>1. The aim of the study was to evaluate the pharmacokinetics of peramivir after single intravenous (i.v.) doses in healthy Chinese subjects.</p> <p>2. In a cross-over study, 12 subjects were given 300 and 600 mg peramivir by i.v. infusion. Blood and urine samples were collected at 17 designated time points and 7 designated intervals up to 36 h post-dose. Plasma and urine concentrations of peramivir were quantified by LC-MS/MS.</p> <p>3. After single i.v. doses of 300 and 600 mg peramivir, <italic>C</italic>_max and AUC_0–<italic>_t</italic> of peramivir were 21.4 ± 3.7, 41.1 ± 5.3 mgċL⁻¹ and 55.90 ± 10.62, 112.1 ± 13.2 mgċh L⁻¹, respectively. <italic>C</italic>_max and AUC increased in proportion to the dose. Within 12 h, accumulative urinary recoveries of peramivir after single i.v. doses of 300 and 600 mg peramivir were 84.31 ± 11.75% and 88.10 ± 7.39%, respectively.</p> <p>4. In healthy Chinese subjects, peramivir displayed linear pharmacokinetics in the range of 300–600 mg, and was primarily excreted via urine as unchanged drug.</p> </abstract>