Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation. Issue 2 (15th August 2014)

• Record Type: Journal Article
• Authors: Christou, Grace; Kekre, Natasha; Petrcich, William; Tokessy, Melanie; Neurath, Doris; Giulivi, Antonio; Saidenberg, Elianna; McDiarmid, Sheryl; Atkins, Harold; Bence‐Bruckler, Isabelle; Bredeson, Christopher; Huebsch, Lothar; Sabloff, Mitchell; Sheppard, Dawn; Tay, Jason; Tinmouth, Alan; Allan, David S.
• Is Part Of: Transfusion. Volume 55:Issue 2(2015)
• Page Start: 253
• Page End: 258
• Publication Date: 2014-08-15
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.12817
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf12817-sec-0001" sec-type="section"> <title>Background</title> <p>Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies after HSCT remain uncertain.</p> </sec> <sec id="trf12817-sec-0002" sec-type="section"> <title>Study Design and Methods</title> <p>A retrospective single‐center cohort study was conducted on 522 patients undergoing HPCT between January 2002 and December 2007. Associations between PLT transfusion events and clinical characteristics with transplant‐related outcomes were assessed using univariate and multivariate analysis.</p> </sec> <sec id="trf12817-sec-0003" sec-type="section"> <title>Results</title> <p>Mean number of PLT transfusion events before Day +60 posttransplant was 7.5 (95% confidence interval, 6.7‐8.4) with greater number of events after allogeneic compared with autologous HPCT (p < 0.01). Univariate and multivariate analysis confirmed that the number of PLT transfusion events was associated with increased 100‐day nonrelapse mortality (p < 0.01), posttransplant length of hospital stay (p < 0.01), need for intensive care unit admission (p < 0.01), and number of organs affected by severe toxicity (p < 0.01).</p> </sec> <sec id="trf12817-sec-0004" sec-type="section"> <title>Conclusion</title> <p>HPCT‐related toxicity and mortality are associated with increased PLT transfusion events. Alternative strategies to reduce PLT transfusions after HPCT may warrant future study.</p> </sec> </abstract>