CD24 Ala57Val polymorphism is associated with spontaneous viral clearance in the HCV‐infected Chinese population. (19th March 2014)

• Record Type: Journal Article
• Authors: Sun, Haibo; Pan, Yu; Wu, Ruihong; Lv, Juan; Chi, Xiumei; Wang, Xiaomei; Tu, ZhengKun; Zhong, Jin; Sun, Bing; Liu, Yang; Jiang, Jing; Niu, Junqi
• Is Part Of: Liver international. Volume 35:Number 3(2015:Mar.)
• Page Start: 786
• Page End: 794
• Publication Date: 2014-03-19
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.12506
• Languages: English
• ISSNs: 1478-3223

Abstract

<abstract abstract-type="main" id="liv12506-abs-0001"> <title>Abstract</title> <sec id="liv12506-sec-0001" sec-type="section"> <title>Background & Aims</title> <p>Host immune response to hepatitis C virus (HCV) is a vital factor involved in both viral clearance and liver disease pathogenesis. <italic>CD24</italic> plays an important role in inflammation and immune response and <italic>CD24</italic> polymorphisms are associated with risk and progression of chronic hepatitis B virus infection. Our study evaluated whether <italic>CD24</italic> polymorphisms affect HCV clearance.</p> </sec> <sec id="liv12506-sec-0002" sec-type="section"> <title>Methods</title> <p>We genotyped 544 chronic hepatitis C (CHC) patients, 78 spontaneous hepatitis C clearance (SHC) patients and 215 healthy controls for <italic>CD24</italic> gene variants at positions −P534, P170, P1527 and <italic>IFNL3</italic> rs12979860 by pyrosequencing. In CHC patients, 362 individuals were treated with a recombinant IFN‐α2b/ribavirin combination for 48 weeks and were followed up for an additional 24 weeks. Lymphocyte <italic>CD24</italic> expression was analysed by flow cytometry.</p> </sec> <sec id="liv12506-sec-0003" sec-type="section"> <title>Results</title> <p>We show that P170 CT and CT/TT genotypes were over‐represented in the SHC group compared to CHC patients (62.8% vs. 47.2% and 75.6% vs. 60.3%, for respective polymorphisms). In multivariate logistic analysis, P170 (<italic>CD24</italic> Ala57Val) polymorphism was an independent predictor of SHC (adjusted OR = 2.11, 95%CI = 1.19–3.73, <italic>P </italic>=<italic> </italic>0.010 for CT genotype; OR = 2.01, 95%CI = 1.15–3.49, <italic>P = </italic>0.014 for CT/TT genotype). No significant associations were found between the <italic>CD24</italic> polymorphisms and treatment‐induced viral clearance in log‐rank analysis and Cox regression analysis. Patients with the CT/TT genotype had greater T‐cell <italic>CD24</italic> expression than patients with the CC genotype.</p> </sec> <sec id="liv12506-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our findings suggest that <italic>CD24</italic> Ala57Val polymorphism and associated variations in <italic>CD24</italic> expression may be an important predictor for SHC, but have no effect on antiviral drug treatment response in Chinese CHC patients.</p> </sec> </abstract>