'Short‐term treatment with methotrexate does not affect microvascular endothelial function in patients with psoriasis'. (21st February 2014)

• Record Type: Journal Article
• Authors: Gyldenløve, M.; Jensen, P.; Løvendorf, M.B.; Zachariae, C.; Hansen, P.R.; Skov, L.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 29:Number 3(2015:Mar.)
• Page Start: 591
• Page End: 594
• Publication Date: 2014-02-21
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12385
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12385-abs-0001"> <title>Abstract</title> <sec id="jdv12385-sec-0001" sec-type="section"> <title>Background</title> <p>Psoriasis is associated with increased risk of cardiovascular disease (CVD), possibly due to chronic low‐grade systemic inflammation. Systemic anti‐inflammatory treatment might reduce the risk of CVD.</p> </sec> <sec id="jdv12385-sec-0002" sec-type="section"> <title>Objective</title> <p>Our aim was to investigate if short‐term treatment with methotrexate influences microvascular endothelial function (MEF), an early surrogate marker of atherosclerosis, in patients with psoriasis.</p> </sec> <sec id="jdv12385-sec-0003" sec-type="section"> <title>Methods</title> <p>We prospectively studied a hospital cohort of patients with psoriasis. Measurements of MEF were performed with the Endo‐PAT2000© device at baseline and after 8–10 weeks of treatment with methotrexate. At the same time points, we recorded anamnestic information, measured body mass index (BMI), waist and hip circumferences and blood pressure, and drew blood samples (lipid profile, HbA1 and hs‐CRP). Psoriasis severity was evaluated by psoriasis area and severity index (PASI) and the dermatology life quality index (DLQI).</p> </sec> <sec id="jdv12385-sec-0004" sec-type="section"> <title>Results</title> <p>A total of 32 patients with psoriasis were included. Median age was 46 (range 18–82) years, and 50% were men. Twenty‐seven patients completed the study. After 8–10 weeks, median PASI had decreased significantly by 6.2 (from 9.8 to 3.6), and DLQI had decreased by 7 (from 9 to 2). No significant changes were observed in MEF, expressed by reactive hyperaemia index and augmentation index. Also, we saw no significant changes in BMI, waist–hip ratio, blood pressure and blood samples.</p> </sec> <sec id="jdv12385-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Short‐term treatment with methotrexate did not affect MEF in patients with psoriasis. Further studies are warranted.</p> </sec> </abstract>