Mycoplasma pneumoniae‐associated mucositis – case report and systematic review of literature. (17th February 2014)

• Record Type: Journal Article
• Authors: Vujic, I.; Shroff, A.; Grzelka, M.; Posch, C.; Monshi, B.; Sanlorenzo, M.; Ortiz‐Urda, S.; Rappersberger, K.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 29:Number 3(2015:Mar.)
• Page Start: 595
• Page End: 598
• Publication Date: 2014-02-17
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12392
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12392-abs-0001"> <title>Abstract</title> <sec id="jdv12392-sec-0001" sec-type="section"> <title>Background</title> <p> <italic>Mycoplasma pneumoniae, </italic> a bacterium known to be a common cause of pneumonia, has been documented to cause complications such as debilitating mucositis previously described as an atypical Stevens–Johnson syndrome without skin lesions. However, in the spectrum of epidermal dermatopathies, the condition is increasingly recognized as a separate entity, now termed <italic>M. pneumoniae</italic>‐associated mucositis (MPAM).</p> </sec> <sec id="jdv12392-sec-0002" sec-type="section"> <title>Objectives</title> <p>We present a case of MPAM and systemically review the literature to discuss diagnostic and therapeutic options.</p> </sec> <sec id="jdv12392-sec-0003" sec-type="section"> <title>Methods</title> <p>A systematic literature search was performed to find studies reporting MPAM in adults. We extracted and analysed patient demographics, disease symptomatology, diagnostic testing and treatment.</p> </sec> <sec id="jdv12392-sec-0004" sec-type="section"> <title>Results</title> <p>Eleven articles, describing 12 patients and our own patient met the predefined criteria and were analysed. Respiratory, ocular and oral symptoms were present in all patients. Therapies predominantly included antibiotics (10 of 13) and immunosuppressive treatment (9 of 13) leading to complete resolution of symptoms in all patients.</p> </sec> <sec id="jdv12392-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Our findings highlight that MPAM should be recognized as a distinct disease entity within the spectrum of epidermal dermatopathies. We discuss and show in our patient why <italic>M. pneumoniae</italic> IgA serum levels could prove to be more reliable diagnostic tools in the MPAM diagnosis than the widely used IgG and IgM titre levels.</p> </sec> </abstract>