Atypical presentation of 'acalculous cholecystitis' with marked isolated hyperbilirubinaemia in patients treated for haematological malignancies. (21st May 2014)

• Record Type: Journal Article
• Authors: Berrevoets, Marvin A.H.; Hermans, John J.; Wanten, Geert J.A.; van der Velden, Walter J.F.M.
• Is Part Of: European journal of haematology. Volume 94:Number 2(2015:Feb.)
• Page Start: 182
• Page End: 185
• Publication Date: 2014-05-21
• Subjects: Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.12357
• Languages: English
• ISSNs: 0902-4441

Abstract

<abstract abstract-type="main" id="ejh12357-abs-0001"> <title>Abstract</title> <p>Four patients diagnosed with haematological malignancies developed an isolated hyperbilirubinaemia following cytarabine‐ and anthracycline‐based chemotherapy. The clinical picture was consistent with acalculous cholecystitis, but ultrasonography did not show the typical gallbladder wall thickening. All patients suffered from severe mucositis with neutropenic enterocolitis. We hypothesise that damage of the mucosa of the gallbladder induced by chemotherapy results in hyperpermeability of the mucosal barrier with bile leakage and isolated hyperbilirubinaemia.</p> </abstract>