Efficacy and safety of injection with poly‐L‐lactic acid compared with hyaluronic acid for correction of nasolabial fold: a randomized, evaluator‐blinded, comparative study. (15th October 2014)

• Record Type: Journal Article
• Authors: Hyun, M. Y.; Lee, Y.; No, Y. A.; Yoo, K. H.; Kim, M. N.; Hong, C. K.; Chang, S. E.; Won, C. H.; Kim, B. J.
• Is Part Of: Clinical and experimental dermatology. Volume 40:Number 2(2015)
• Page Start: 129
• Page End: 135
• Publication Date: 2014-10-15
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.12499
• Languages: English
• ISSNs: 0307-6938

Abstract

<abstract abstract-type="main" id="ced12499-abs-0001"> <title>Summary</title> <sec id="ced12499-sec-0001" sec-type="section"> <title>Background</title> <p>Hyaluronic acid (HA) fillers and poly‐L‐lactic acid (PLA) fillers are frequently used to correct facial wrinkles.</p> </sec> <sec id="ced12499-sec-0002" sec-type="section"> <title>Aim</title> <p>To compare the efficacy and safety of a novel injectable poly‐L‐lactic acid (PLA) filler and a well‐studied biphasic HA filler for the treatment of moderate to severe nasolabial folds.</p> </sec> <sec id="ced12499-sec-0003" sec-type="section"> <title>Methods</title> <p>In this multicentre, randomized, evaluator‐blinded, comparative study, subjects were randomized for injections with PLA or HA into both nasolabial folds. Efficacy was determined by calculating the change in Wrinkle Severity Rating Scale (WSRS) relative to baseline. Local safety was assessed by reported adverse events.</p> </sec> <sec id="ced12499-sec-0004" sec-type="section"> <title>Results</title> <p>At week 24, mean improvement in WSRS from baseline was 2.09 ± 0.68 for the PLA side and 1.54 ± 0.65 for the HA side. Both injections were well tolerated, and the adverse reactions were mild and transient in most cases.</p> </sec> <sec id="ced12499-sec-0005" sec-type="section"> <title>Conclusions</title> <p>PLA provides noninferior efficacy compared with HA 6 months after being used to treat moderate to severe nasolabial folds.</p> </sec> </abstract>