Adoptive T Cell Immunotherapy for Treatment of Ganciclovir‐Resistant Cytomegalovirus Disease in a Renal Transplant Recipient. Issue 3 (3rd February 2015)

• Record Type: Journal Article
• Authors: Macesic, N.; Langsford, D.; Nicholls, K.; Hughes, P.; Gottlieb, D. J.; Clancy, L.; Blyth, E.; Micklethwaite, K.; Withers, B.; Majumdar, S.; Fleming, S.; Sasadeusz, J.
• Is Part Of: American journal of transplantation. Volume 15:Issue 3(2015:Mar.)
• Page Start: 827
• Page End: 832
• Publication Date: 2015-02-03
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.13023
• Languages: English
• ISSNs: 1600-6135

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ajt13023-sec-0001" sec-type="section"> <p>Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir‐resistant CMV are limited. We describe a case of ganciclovir‐resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy‐associated glomerulopathy. Adoptive T cell immunotherapy using CMV‐specific T cells from a donor bank was used as salvage therapy. This report is a proof‐of‐concept of the clinical and logistical feasibility of this therapy in SOT recipients.</p> </sec> </abstract>