Dalbergia odorifera Extract Ameliorates UVB‐Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins. Issue 1 (25th January 2015) - Ham, Sun Ah
Abstract Preclinical Research Emerging evidence suggests that Dalbergia odorifera T. Chen (Leguminosae), an indigenous medicinal herb, has therapeutic potential. This study examined the antiwrinkle effects of ethanol extracts of D. odorifera in UVB‐irradiated human skin cells. Ethanol extracts of D. odorifera and thier constituents, dalbergin and sativanone, induced expression of collagen type I and transforming growth factor (TGF)‐β1 in human dermal fibroblasts. In HR‐1 hairless mice exposed to UVB, the ethanol extract reduced wrinkle formation and skin thickness. This inhibitory effect of ethanol extract was associated with the restoration of collagen type I, TGF‐β1, and elastin to levels approaching those in skin tissues not exposed to UVB, which was accompanied by the reduction of matrix metalloproteinase‐2 and upregulation of tissue inhibitors of metalloproteinase (TIMP)‐2 and TIMP‐3 in skin tissue exposed to UVB. These results suggest that the ethanol extracts prevent some effects of photoaging and maintain skin integrity by regulating the degradation of the extracellular matrix proteins. © 2015 Wiley Periodicals, Inc. Drug Dev Res 76 : 48–56, 2015