Back Cover: Rational Design of Selenadiazole Derivatives to Antagonize Hyperglycemia‐Induced Drug Resistance in Cancer Cells (Chem. Asian J. 3/2015). Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Liu, Yuedan; Luo, Yi; Li, Xiaoling; Zheng, Wenjie; Chen, Tianfeng
• Is Part Of: Chemistry, an Asian journal. Volume 10:Issue 3(2015:Mar.)
• Page Start: 768
• Page End: 768
• Publication Date: 2015-03
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201590008
• Languages: English
• ISSNs: 1861-4728

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Medicinal Chemistry</bold> Hyperglycemia could be one of the most important reasons accounting for the chemoresistance of cancer patients with diabetes to therapeutics. In their Full Paper on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 642 ff.</ext-link>, featured on the Back Cover, Xiaoling Li, Tianfeng Chen et al. report on the rational design of selenadiazole derivatives that could antagonize the drug resistance of HepG2 hepatocellular carcinoma cells to anticancer drugs under simulated diabetes conditions, through overproduction of reactive oxygen species (ROS), activation of adenosine monophosphate‐activated kinase (AMPK), and inhibition of mTOR Complex1 (mTORC1). This study may provide an effective strategy to design selenadiazole derivatives with the potency to overcome hyperglycemia‐induced drug resistance.<xref ref-type="link" rid="for003" /><chem-struct-wrap id="for003" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3xbzdfvk" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></chem-struct-wrap><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3xbzdqpz" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>