Direct N‐Methylation Reaction Using DMSO as One‐Carbon Bridge: Convenient Access to Heterocycle‐Containing β‐Amino Ketones. Issue 3 (7th January 2015)

• Record Type: Journal Article
• Authors: Sun, Kai; Wang, Xin; Jiang, Yongqing; Lv, Yunhe; Zhang, Liping; Xiao, Beibei; Li, Donghui; Zhu, Zhonghong; Liu, Lin
• Is Part Of: Chemistry, an Asian journal. Volume 10:Issue 3(2015:Mar.)
• Page Start: 536
• Page End: 539
• Publication Date: 2015-01-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201403358
• Languages: English
• ISSNs: 1861-4728

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel oxidative CS bond cleavage reaction of DMSO for dual CC and CN bond formation is described. A series of acetyl heteroarenes could be selectively converted into the corresponding β‐amino ketones, which are frequently found in biologically active compounds and pharmaceuticals. DMSO acted in this reaction not only as the solvent but also as a one‐carbon bridge.</p> </abstract>