A Fast and Activatable Cross‐Linking Strategy for Hydrogel Formation. (23rd December 2014)

• Record Type: Journal Article
• Authors: Jonker, Anika M.; Borrmann, Annika; van Eck, Ernst R. H.; van Delft, Floris L.; Löwik, Dennis W. P. M.; van Hest, Jan C. M.
• Is Part Of: Advanced materials. Volume 27:Number 7(2015)
• Page Start: 1235
• Page End: 1240
• Publication Date: 2014-12-23
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201404448
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201404448-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Strain‐promoted oxidation‐controlled cyclo­octyne‐1, 2‐quinone cycloaddition (SPOCQ)</bold> is a fast and activatable cross‐linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ‐formed hydrogels can be functionalized in one‐pot with an azido‐containing moiety using SPAAC cross‐linking. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3w99kd31" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>