Effects of acute administration of mazindol on brain energy metabolism in adult mice. Issue 3 (19th September 2013)

• Record Type: Journal Article
• Authors: Gonçalves, Cinara Ludvig; Scaini, Giselli; Rezin, Gislaine Tezza; Jeremias, Isabela Casagrande; Bez, Gisele Daiane; Daufenbach, Juliana Felipe; Gomes, Lara Mezari; Ferreira, Gabriela Kozuchovski; Zugno, Alexandra Ioppi; Streck, Emilio Luiz
• Is Part Of: Acta neuropsychiatrica. Volume 26:Issue 3(2014:Jun.)
• Page Start: 146
• Page End: 154
• Publication Date: 2013-09-19
• Subjects: Neuropsychiatry -- Periodicals; 616.89
• DOI: 10.1017/neu.2013.43
• Languages: English
• ISSNs: 0924-2708

Abstract

<abstract abstract-type="normal"> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <sec id="abs1" sec-type="general"> <title>Objectives</title> <p>Mazindol is a sympathomimetic amine, widely used as an anorectic agent in the treatment of obesity. This drug causes psychostimulant effects because of its pharmacological profile similar to amphetamine, acting like a monoamine reuptake inhibitor. However, the mechanisms underlying the action of mazindol are still not clearly understood.</p> </sec> <sec id="abs2" sec-type="methods"> <title>Methods</title> <p>Swiss mice received a single acute administration of mazindol (0.25, 1.25 and 2.5 mg/kg, ip) or saline. After 2 h, the animals were killed by decapitation; the brain was removed and used for the evaluation of activities of mitochondrial respiratory chain complexes, Krebs cycle enzymes and creatine kinase.</p> </sec> <sec id="abs3" sec-type="results"> <title>Results</title> <p>Acute administration of mazindol decreased complex I activity only in the hippocampus. Complex IV activity was increased in the cerebellum (2.5 mg/kg) and cerebral cortex (0.25 mg/kg). Citrate synthase activity was increased in the cerebellum (1.25 mg/kg) and cerebral cortex (1.25 mg/kg), and creatine kinase activity was increased in the cerebellum (1.25 mg/kg).</p> </sec> <sec id="abs4" sec-type="conclusion"> <title>Conclusion</title> <p>We suggest that the inhibition of complex I in the hippocampus only and activation of complex IV, citrate synthase and creatine kinase occurs because of a stimulus effect of mazindol in the central nervous system, which causes a direct impairment on energy metabolism.</p> </sec> </abstract>