TaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men. Issue 6 (28th March 2014)

• Record Type: Journal Article
• Authors: Gammon, Cheryl S.; Minihane, Anne M.; Kruger, Rozanne; Conlon, Cathryn A.; von Hurst, Pamela R.; Jones, Beatrix; Stonehouse, Welma
• Is Part Of: British journal of nutrition. Volume 111:Issue 6(2014)
• Page Start: 1077
• Page End: 1084
• Publication Date: 2014-03-28
• Subjects: Nutrition -- Periodicals; 572.4
• DOI: 10.1017/S0007114513003437
• Languages: English
• ISSNs: 0007-1145

Abstract

<abstract abstract-type="normal"> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <p>Fruit and vegetables are key elements of a cardioprotective diet, but benefits on plasma lipids, especially HDL-cholesterol (HDL-C), are inconsistent both within and between studies. In the present study, we investigated whether four selected HDL-C-related polymorphisms (cholesteryl ester transfer protein (<italic>CETP</italic>) <italic>Taq1B</italic>, <italic>APOA1</italic> − 75G/A, hepatic lipase (<italic>LIPC</italic>) − 514C → T, and endothelial lipase (<italic>LIPG</italic>) I24582) modulate the plasma lipid response to a kiwifruit intervention. This is a retrospective analysis of data collected during a 12-week randomised controlled cross-over trial. A total of eighty-five hypercholesterolaemic men completed a 4-week healthy diet run-in period before being randomised to one of two 4-week intervention sequences of two green kiwifruit/d plus healthy diet (kiwifruit intervention) or healthy diet alone (control intervention). The measurement of anthropometric parameters and collection of fasting blood samples were carried out at baseline 1 and after the run-in (baseline 2) and intervention periods. At baseline 2, <italic>B1/B1</italic> homozygotes of the <italic>CETP</italic><italic>Taq1B</italic> gene had significantly higher total cholesterol:HDL-C, TAG:HDL-C, and apoB:apoA1 ratios and small-dense LDL concentrations than <italic>B2</italic> carriers. A significant <italic>CETP Taq1B</italic> genotype × intervention interaction was observed for the TAG:HDL-C ratio (<italic>P</italic>= 0·03). <italic>B1/B1</italic> homozygotes had a significantly lower TAG:HDL-C ( − 0·23 (<sc>sd</sc> 0·58) mmol/l; <italic>P</italic>= 0·03) ratio after the kiwifruit intervention than after the control intervention, whereas the ratio of <italic>B2</italic> carriers was not affected. The lipid response was not affected by other gene polymorphisms. In conclusion, the significant decrease in the TAG:HDL-C ratio in <italic>B1/B1</italic> homozygotes suggests that regular inclusion of green kiwifruit as part of a healthy diet may improve the lipid profiles of hypercholesterolaemic men with this genotype.</p> </abstract>