Roles of TGF-beta and periostin in fibrosclerosis in patients with IgG4-related diseases. (December 2013)

• Record Type: Journal Article
• Authors: Ohta, Nobuo; Kurakami, Kazuya; Ishida, Akihiro; Furukawa, Takatoshi; Suzuki, Yusuke; Aoyagi, Masaru; Matsubara, Atsushi; Izuhara, Kenji; Kakehata, Seiji
• Is Part Of: Acta oto-laryngologica. Volume 133:Number 12(2013)
• Page Start: 1322
• Page End: 1327
• Publication Date: 2013-12
• Subjects: Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.3109/00016489.2013.831187
• Languages: English
• ISSNs: 0001-6489

Abstract

<abstract> <title>Abstract</title> <p> <italic>Conclusion:</italic> These results suggest that transforming growth factor (TGF)-beta and periostin could be useful as novel biomarkers and therapeutic targets in IgG4-related disease.</p> <p> <italic>Objectives:</italic>IgG4-related disease is an uncommon fibrosclerosing and inflammatory mass-forming disease that can be systemic or can affect single organs. To clarify the roles of TGF-beta, periostin, and interleukin (IL)-13 in the pathogenesis of IgG4-related disease, we studied a total of 36 serum and 11 tissue samples from patients with IgG4-related disease.</p> <p> <italic>Methods:</italic> This was a retrospective clinical study. The patient group consisted of six females and seven males (average age 60 years, range 38–74 years). Serum IgG4 levels, the tissue density of IgG4-positive plasmacytes, and the expression of TGF-beta and periostin in the affected tissues were examined immunohistochemically.</p> <p> <italic>Results:</italic> Serum IgG4 levels were elevated in all patients (mean 776.6, range 185–2820 mg/dl), and IgG4-positive plasmacytes were observed in the affected salivary glands. Seven patients with prominent infiltration of the involved glands with IgG4-positive plasmacytes had fatal systemic complications, including pancreatitis, after swelling of the salivary glands. Overexpression of TGF-beta and periostin was observed in affected tissues obtained from these patients.</p> </abstract>