Contribution of MDR1 gene polymorphisms on IBD predisposition and response to glucocorticoids in IBD in a Chinese population. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Yang, Qing Fan; Chen, Bai Li; Zhang, Qing Sen; Zhu, Zhen Hua; Hu, Bin; He, Yao; Gao, Xiang; Wang, Yi Ming; Hu, Pin Jin; Chen, Min Hu; Zeng, Zhi Rong
• Is Part Of: Journal of digestive diseases. Volume 16:Issue 1(2015:Jan.)
• Page Start: 22
• Page End: 30
• Publication Date: 2015-01
• Subjects: Digestive organs -- Diseases -- Periodicals; Gastroenterology -- Periodicals; 616.3
• DOI: 10.1111/1751-2980.12205
• Languages: English
• ISSNs: 1751-2972

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="cdd12205-sec-0001" sec-type="section"> <title>Objective</title> <p>The cornerstone of conventional treatment for inflammatory bowel disease (IBD) is glucocorticoid (GC). Single nucleotide polymorphisms (SNPs) of genes such as multidrug resistance 1 (<italic>MDR1</italic>) are related to patient's response to GC, and <italic>MDR1</italic> polymorphisms are associated with susceptibility to IBD in Caucasians. We aimed to investigate whether the polymorphisms of five genes including <italic>MDR1</italic> influence the response to GC in Chinese patients and the relationship between <italic>MDR1</italic> and IBD susceptibility.</p> </sec> <sec id="cdd12205-sec-0002" sec-type="section"> <title>Methods</title> <p>SNPs were selected and genotyped in 156 IBD patients treated with GC and 223 healthy controls. Patients were evaluated and classified as GC‐dependent, GC‐resistant or responsive to GC after treatment.</p> </sec> <sec id="cdd12205-sec-0003" sec-type="section"> <title>Results</title> <p>The CC genotypes of rs1128503 and rs1045642 in <italic>MDR1</italic> gene were more frequent in Crohn's disease (CD) patients who were GC‐dependent than in those responsive to GC (odds ratio [OR] 6.583, 95% confidence interval [CI] 1.760–24.628, <italic>P</italic> = 0.019 and OR 3.873, 95% CI 1.578–9.506, <italic>P</italic> = 0.009, respectively). The G allele of <italic>MDR1</italic> rs2032582 was less frequent among CD patients than in controls (OR 0.668, 95% CI 0.484–0.921, <italic>P</italic> = 0.014). G allele carriers were also less likely to develop non‐stricturing and non‐penetrating CD (OR 0.661, 95% CI 0.462–0.946, <italic>P</italic> = 0.023) and ileocolonic CD (OR 0.669, 95% CI 0.472–0.948, <italic>P</italic> = 0.024).</p> </sec> <sec id="cdd12205-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Polymorphisms of <italic>MDR1</italic> are associated with patient's GC response and a predisposition to CD in Chinese population. Further studies are needed to elucidate the role of <italic>MDR1</italic> polymorphisms in IBD and that as genetic markers for GC response.</p> </sec> </abstract>