Weight‐neutral effect of once‐daily insulin detemir in Chinese type 2 diabetes patients: Subgroup analysis of the SOLVE study 一天一次地特胰岛素对中国2型糖尿病患者体重的中性影响：SOLVE研究亚组分析. (4th September 2014)

• Record Type: Journal Article
• Authors: Pan, Changyu; Han, Ping; Ji, Linong; Ji, Qiuhe; Lu, Juming; Lin, Jing; Liu, Jie; Su, Benli; Shi, Jingmei; Wang, Penghua
• Is Part Of: Journal of diabetes. Volume 7:Number 2(2015:Apr.)
• Page Start: 222
• Page End: 230
• Publication Date: 2014-09-04
• Subjects: Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12179
• Languages: English
• ISSNs: 1753-0393

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jdb12179-sec-0001" sec-type="section"> <title>Background</title> <p>The present subanalysis of the Study of Once Daily Levemir (SOLVE) study was to evaluate the safety and efficacy of once‐daily insulin detemir as add‐on to oral antidiabetic drugs (OADs) in Chinese type 2 diabetes patients according to body mass index in a real‐life setting.</p> </sec> <sec id="jdb12179-sec-0002" sec-type="section"> <title>Methods</title> <p>In all, 3272 eligible patients who were treated with diet, exercise, and one or more OAD were prescribed once‐daily insulin detemir by their physician according to routine clinical practice and were followed‐up for 24 weeks. The incidence of serious adverse reactions (SADRs), including major hypoglycemia, was the primary endpoint. Subanalyses were performed on patients in the following BMI groups: normal weight (BMI < 25 kg/m<sup>2</sup>); overweight (25 ≤ BMI < 30 kg/m<sup>2</sup>); and obese (BMI ≥ 30 kg/m<sup>2</sup>).</p> </sec> <sec id="jdb12179-sec-0003" sec-type="section"> <title>Results</title> <p>No SADRs were reported during the study. Significant improvements in glycemic levels were observed in all subgroups. For normal weight, overweight, and obese patients, the mean change in HbA1c (%/[mmol/mol]) was −1.26/−14, −1.09/−12, and −1.06/−12, respectively. The mean change in fasting plasma glucose in normal weight, overweight, and obese patients was −2.77, −2.57, and −2.71 mmol/L, respectively. Slight weight gain (0.25 kg), slight weight loss (–0.36 kg), and weight loss (–1.32 kg) were observed in the normal weight, overweight, and obese patients, respectively (<italic>P</italic> < 0.001). Linear regression analysis revealed a negative relationship between weight change and baseline BMI (slope = −0.16; <italic>P</italic> < 0.001).</p> </sec> <sec id="jdb12179-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Once‐daily insulin detemir as add‐on to OADs in Chinese patients with type 2 diabetes showed effective glycemic control and a low risk of hypoglycemia. Weight‐neutral effects were observed in different BMI subgroups.</p> </sec> </abstract>