Effects of an Accelerated Intravenous Iron Regimen in Hospitalized Patients With Advanced Heart Failure and Iron Deficiency. Issue 1 (29th December 2014)

• Record Type: Journal Article
• Authors: Reed, Brent N.; Blair, Elizabeth A.; Thudium, Emily M.; Waters, Sarah B.; Sueta, Carla A.; Jensen, Brian C.; Rodgers, Jo E.
• Is Part Of: Pharmacotherapy. Volume 35:Issue 1(2015)
• Page Start: 64
• Page End: 71
• Publication Date: 2014-12-29
• Subjects: Chemotherapy -- Periodicals; Pharmacology -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1002/phar.1525
• Languages: English
• ISSNs: 0277-0008

Abstract

<abstract abstract-type="main" id="phar1525-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="phar1525-sec-0001" sec-type="section"> <title>Study Objective</title> <p>To assess the short‐term efficacy and safety of an accelerated intravenous iron regimen in hospitalized patients with heart failure and iron deficiency.</p> </sec> <sec id="phar1525-sec-0002" sec-type="section"> <title>Design</title> <p>Prospective, single‐arm, open‐label study.</p> </sec> <sec id="phar1525-sec-0003" sec-type="section"> <title>Setting</title> <p>Large tertiary care medical center.</p> </sec> <sec id="phar1525-sec-0004" sec-type="section"> <title>Patients</title> <p>Thirteen patients with New York Heart Association class III–IV heart failure, anemia (hemoglobin level ≤ 12.0 g/dl), and iron deficiency (ferritin level < 100 ng/ml, or ferritin level of 100–300 ng/ml with transferrin saturation < 20%) hospitalized between April 2011 and December 2013.</p> </sec> <sec id="phar1525-sec-0005" sec-type="section"> <title>Intervention</title> <p>All patients received sodium ferric gluconate 250 mg in 100 ml of normal saline intravenously over 2 hours twice/day until the iron deficit was corrected or the patient was discharged.</p> </sec> <sec id="phar1525-sec-0006" sec-type="section"> <title>Measurements and Main Results</title> <p>Changes in hematologic parameters were assessed at 1–4 weeks after therapy. Patients received a mean ± standard deviation (SD) total iron dose of 1269 ± 207 mg over 3.4 ± 1.0 days. After a mean ± SD follow‐up of 13.1 ± 5.6 days, intravenous iron increased hemoglobin level by 1.2 g/dl (95% confidence interval [CI] 0.45–1.9, p=0.005), ferritin level by 364.2 ng/ml (95% CI 129.7–598.7, p=0.007), and transferrin saturation by 10.5% (95% CI 6.5–14.6%, p<0.001). Changes in hemoglobin level did not correlate with volume status, as determined by differences in body weight. No significant changes in blood pressure or heart rate were observed. Adverse events were few and minor in severity (e.g., nausea, constipation, and abdominal discomfort).</p> </sec> <sec id="phar1525-sec-0007" sec-type="section"> <title>Conclusion</title> <p>An accelerated intravenous iron regimen improved hematologic parameters and was well tolerated in hospitalized patients with advanced heart failure. A randomized multicenter trial comparing this regimen with placebo is warranted.</p> </sec> </abstract>