A novel pH‐responsive interpolyelectrolyte hydrogel complex for the oral delivery of levodopa. Part I. IPEC modeling and synthesis. Issue 3 (25th June 2014)

• Record Type: Journal Article
• Authors: Ngwuluka, Ndidi C.; Choonara, Yahya E.; Kumar, Pradeep; du Toit, Lisa C.; Khan, Riaz A.; Pillay, Viness
• Is Part Of: Journal of biomedical materials research. Volume 103:Issue 3(2015:Mar.)
• Page Start: 1077
• Page End: 1084
• Publication Date: 2014-06-25
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35259
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>This study was undertaken to synthesize an interpolyelectrolyte complex (IPEC) of polymethacrylate (E100) and sodium carboxymethylcellulose (NaCMC) to form a polymeric hydrogel material for application in specialized oral drug delivery of sensitive levodopa. Computational modeling was employed to proffer insight into the interactions between the polymers. In addition, the reactional profile of NaCMC and polymethacrylate was elucidated using molecular mechanics energy relationships (MMER) and molecular dynamics simulations (MDS) by exploring the spatial disposition of NaCMC and E100 with respect to each other. Computational modeling revealed that the formation of the IPEC was due to strong ionic associations, hydrogen bonding, and hydrophilic interactions. The computational results corroborated well with the experimental and the analytical data. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1077–1084, 2015.</p> </abstract>