Direct Asymmetric Dearomatization of 2‐Naphthols by Scandium‐Catalyzed Electrophilic Amination1. (7th January 2015)

• Record Type: Journal Article
• Authors: Nan, Jiang; Liu, Jingjing; Zheng, Huayu; Zuo, Zhijun; Hou, Lei; Hu, Huaiming; Wang, Yaoyu; Luan, Xinjun
• Is Part Of: Angewandte Chemie. Volume 127:Number 8(2015)
• Page Start: 2386
• Page End: 2390
• Publication Date: 2015-01-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201409565
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Catalytic asymmetric aminative dearomatization of 1‐substituted 2‐naphthols was successfully implemented with electrophilic azodicarboxylates under the catalysis of chiral Sc^III/pybox complexes. This intermolecular reaction represents a hitherto unknown enantioselective CN bond‐forming process through direct dearomatization of phenolic compounds to generate chiral nitrogen‐containing quaternary carbon stereocenters.</p> </abstract>