Low‐intensity running exercise enhances the capillary volume and pro‐angiogenic factors in the soleus muscle of type 2 diabetic rats. Issue 3 (6th January 2015)

• Record Type: Journal Article
• Authors: Kondo, Hiroyo; Fujino, Hidemi; Murakami, Shinichiro; Tanaka, Masayuki; Kanazashi, Miho; Nagatomo, Fumiko; Ishihara, Akihiko; Roy, Roland R.
• Is Part Of: Muscle & nerve. Volume 51:Issue 3(2015:Mar.)
• Page Start: 391
• Page End: 399
• Publication Date: 2015-01-06
• Subjects: Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.24316
• Languages: English
• ISSNs: 0148-639X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p> <italic>Introduction</italic>: We determined the effects of low‐intensity exercise on the three‐dimensional capillary structure and associated angiogenic factors in the soleus muscle of Goto‐Kakizaki (GK) diabetic rats. <italic>Methods</italic>: Four groups of male rats were studied: sedentary nondiabetic (Con), exercised nondiabetic control (Ex), sedentary GK, and exercised GK (GK+Ex). Rats in the Ex and GK+Ex groups were subjected to chronic low‐intensity running on a treadmill (15 m/min, 60 min/session, 5 sessions/week for 3 weeks). <italic>Results</italic>: Although mean capillary volume and diameter were lower in the GK compared with all other groups, low‐intensity exercise increased both of these measures in GK rats. Mitochondrial markers, <italic>i.e</italic>., SDH activity and PGC‐1α expression, and the levels of angiogenic factors were higher in the GK+Ex than all other groups. Exercise increased vascular endothelial growth factor (VEGF) protein levels and the VEGF‐to‐TSP‐1 ratio, an indicator of angiogenesis, in GK rats. <italic>Conclusions</italic>: Combined, the results indicate that low‐intensity exercise reduces some of the microcirculatory complications in type 2 diabetic muscles. <italic>Muscle Nerve</italic> 51: 391–399, 2015</p> </abstract>