ProKinO: A Unified Resource for Mining the Cancer Kinome. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: McSkimming, Daniel Ian; Dastgheib, Shima; Talevich, Eric; Narayanan, Anish; Katiyar, Samiksha; Taylor, Susan S.; Kochut, Krys; Kannan, Natarajan
• Is Part Of: Human mutation. Volume 36:Issue 2(2015:Feb.)
• Page Start: 175
• Page End: 186
• Publication Date: 2015-02
• Subjects: Human chromosome abnormalities -- Periodicals; Mutation (Biology) -- Periodicals; 616.04205
• DOI: 10.1002/humu.22726
• Languages: English
• ISSNs: 1059-7794

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="humu22726-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Here, we demonstrate the utility of an integrative ontological framework in analyzing the cancer kinome and in generating testable hypotheses for experimental studies. Through the iterative process of aggregate ontology querying, hypothesis generation and experimental validation, we identify a novel mutational hotspot in the αC‐β4 loop of the kinase domain and demonstrate the functional impact of the identified variants in epidermal growth factor receptor (EGFR) constitutive activity and inhibitor sensitivity. We provide this unified resource, ProKinO, for the kinase and cancer community at <ext-link ext-link-type="uri" xlink:href="http://vulcan.cs.uga.edu/prokino" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">http://vulcan.cs.uga.edu/prokino</ext-link>. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3r5jm5dt" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>