Granulocyte-colony stimulating factor response is superior to neutropenia duration in predicting the risk of infection after high-dose chemotherapy for myeloma and lymphoma. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Straka, Christian; Salwender, Hans; Schnabel, Brigitte; Sandherr, Michael; Wandt, Hannes; Hübel, Kai; Scheid, Christof; Metzner, Bernd; Hentrich, Marcus; Franke, Daniel; Weidenegger, Gloria; Freund, Mathias; Sezer, Orhan; Einsele, Hermann; Hinke, Axel; Emmerich, Bertold
• Is Part Of: Leukemia & lymphoma. Volume 56:Issue 2(2015:Feb.)
• Page Start: 368
• Page End: 376
• Publication Date: 2015-02
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2014.919631
• Languages: English
• ISSNs: 1042-8194

Abstract

<abstract> <title>Abstract</title> <p>The patient granulocyte-colony stimulating factor (G-CSF) response is represented by the leukocyte peak in the blood induced by a single dose of G-CSF after chemotherapy, and is correlated with subsequent neutropenic infection risk. General patterns for a meaningful risk group stratification, have not yet been determined. Two independent data sets including a total of 306 cases with myeloma or lymphoma and autologous blood stem cell transplant were available. An infection susceptibility curve plotted according to ranked G-CSF responses from a multicenter study reproduced and validated a curve from the previous single center. Two trend changes were seen within these curves at around 11 000 and 22 000 leukocytes/μL, which separated three groups with a high, medium and low risk of infection. While G-CSF response is related to the consecutive duration of neutropenia, it retains additional independent predictive information for infection risk (<italic>p</italic> &lt; 0.0001) and, more important, is a tool available before the onset of the critical period.</p> </abstract>