Clinical significance of intensive endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma. (December 2013)

• Record Type: Journal Article
• Authors: Kim, Do Hoon; Gong, Eun Jeong; Jung, Hwoon-Yong; Lim, Hyun; Ahn, Ji Yong; Choi, Kwi-Sook; Lee, Jeong Hoon; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Kim, Jin Ho; Roh, Jong-Lyel; Choi, Seung-Ho; Nam, Soon Yuhl; Kim, Sang Yoon; Baek, Seunghee
• Is Part Of: Scandinavian journal of gastroenterology. Volume 49:Number 12(2014)
• Page Start: 1486
• Page End: 1492
• Publication Date: 2013-12
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.3109/00365521.2013.832369
• Languages: English
• ISSNs: 0036-5521

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Objectives. </italic> </bold>Patients with head and neck squamous cell carcinoma (HNSCC) often develop second primary tumors in the upper aerodigestive tract. Early detection of synchronous esophageal squamous cell neoplasm (ESCN) is important because the prognosis of HNSCC can be affected by the statuses of second primary tumors. <bold><italic>Methods. </italic></bold>In a prospective study, 308 patients with HNSCC were screened for synchronous ESCN between May 2010 and April 2012. All patients underwent conventional white-light endoscopic examination with Lugol chromoendoscopy and narrow band image. <bold><italic>Results.</italic></bold> The median age was 61 years (range, 26–87 years), and the male-to-female ratio was 4.2:1. Two hundred and thirty-four patients (76.0%) were current or ex-smokers, 207 patients (67.2%) had a history of alcohol consumption and 56 patients (18.2%) had previous history of cancer. Synchronous ESCN was detected in 22 patients (7.1%), and most patients were at an early stage. The locations of index HNSCC in these patients were as follows: hypopharynx (<italic>n</italic> = 12), larynx (<italic>n</italic> = 6), oropharynx (<italic>n</italic> = 2) and oral cavity (<italic>n</italic> = 2). Synchronous ESCN was detected in 25.5% (12/47) of hypopharyngeal cancer and in 27.8% (15/54) of HNSCC involving the pyriform sinus. Multivariate analysis showed that smoking (current smoker <italic>vs</italic>. never smoker, Odds Ratio [OR] 8.3, <italic>p</italic> = 0.028), a history of cancer (OR 5.0, <italic>p</italic> = 0.002) and pyriform sinus involvement (OR 9.2, <italic>p</italic> < 0.0001) increased the risk of developing synchronous ESCN. <bold><italic>Conclusions. </italic></bold>Patients with HNSCC, especially those who are current smokers, have a history of cancer and have pyriform sinus involvement, should undergo intensive endoscopic screening to detect synchronous ESCN.</p> </abstract>