Proteins from the 18 glycosyl hydrolase family are associated with kidney dysfunction in patients with diabetes type 2. (February 2015)

• Record Type: Journal Article
• Authors: Żurawska-Płaksej, Ewa; Ługowska, Agnieszka; Hetmańczyk, Katarzyna; Knapik-Kordecka, Maria; Adamiec, Rajmund; Piwowar, Agnieszka
• Is Part Of: Biomarkers. Volume 20:Number 1(2015)
• Page Start: 52
• Page End: 57
• Publication Date: 2015-02
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2014.992475
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives</italic>: To investigate chitotriosidase (CHIT1) activity and chitinase-3-like protein 1 (YKL-40) concentration in plasma of type 2 diabetic patients and evaluate their relationship with kidney dysfunction.</p> <p> <italic>Materials and methods</italic>: 94 diabetic subjects and 33 controls were enrolled in the study. Plasma CHIT1 activity and YKL-40 concentration were measured along with routine laboratory parameters.</p> <p> <italic>Results</italic>: Levels of CHIT1 and YKL-40 in plasma of type 2 diabetic patients increased progressively with the degree of albuminuria. CHIT1 discriminated normoalbuminuric subjects from those with abnormal albuminuria better than YKL-40.</p> <p> <italic>Conclusions</italic>: CHIT1represent a supportive biomarker connected with development of diabetic vascular complications, especially kidney dysfunction.</p> </abstract>