Anti-Müllerian hormone as a marker of premature ovarian aging in autoimmune thyroid disease. (February 2015)

• Record Type: Journal Article
• Authors: Saglam, Fatma; Onal, Eda Demir; Ersoy, Reyhan; Koca, Cemile; Ergin, Merve; Erel, Ozcan; Cakir, Bekir
• Is Part Of: Gynecological endocrinology. Volume 31:Number 2(2015:Feb.)
• Page Start: 165
• Page End: 168
• Publication Date: 2015-02
• Subjects: Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2014.973391
• Languages: English
• ISSNs: 0951-3590

Abstract

<abstract> <title>Abstract</title> <p>There is an increased incidence of autoimmune thyroid disease (AITD) in women with infertility. We hypothesized that serum anti-Müllerian hormone (AMH) levels will be lower in premenopausal women with AITD than controls. We evaluated ovarian reserve in women with AITD (<italic>n</italic> = 85) and healthy controls (<italic>n</italic> = 80), all &lt;40 years old. Detailed data on reproductive history were obtained. Gonadotrophins, steroids, AMH, and inhibin B levels were measured during the follicular phase. The number of pregnancies as well as live births was lower in women with AITD (<italic>p </italic>&lt; 0.01). No difference was observed in terms of FSH, estradiol, and inhibin B. AMH levels were lower in AITD women than in controls (1.16 + 0.17 versus 1.28 + 0.25 ng/ml, mean + SD, <italic>p</italic> = 0.001). According to the multiple regression analysis, even after age adjustment, AITD was significantly and independently affected AMH levels (<italic>t</italic> = 2.674, <italic>p</italic> = 0.008). Women with AITD seem to have a diminished ovarian follicular reserve and measurement of serum AMH level has the potential to be used to predict this comorbidity.</p> </abstract>