4-Methoxymethyl-2, 3, 5, 6-tetrafluorobenzyl alcohol as a urinary biomarker for monitoring of metofluthrin, a fluorine-containing pyrethroid, in exposed rats. (February 2015)

• Record Type: Journal Article
• Authors: Yoshida, Toshiaki
• Is Part Of: Biomarkers. Volume 20:Number 1(2015)
• Page Start: 71
• Page End: 76
• Publication Date: 2015-02
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2014.992814
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: A fluorine-containing pyrethroid metofluthrin is widely used recently in mosquito repellents.</p> <p> <italic>Objective</italic>: The urinary excretion kinetics of its metabolites was evaluated in rats to establish an optimal biomarker for monitoring metofluthrin exposure of the general population.</p> <p> <italic>Methods and results</italic>: After metofluthrin had been administered intraperitoneally to rats, the urinary excretion kinetics of the major metofluthrin metabolites was evaluated by moment analysis. The urinary excretion amounts of 4-methoxymethyl-2, 3, 5, 6-tetrafluorobenzyl alcohol were estimated to be proportional to the absorption amounts over a wide exposure range.</p> <p> <italic>Conclusion</italic>: Urinary 4-methoxymethyl-2, 3, 5, 6-tetrafluorobenzyl alcohol was considered to be an optimal biomarker for metofluthrin exposure.</p> </abstract>