PEAR1 is not a human hypertension-susceptibility gene. (February 2015)

• Record Type: Journal Article
• Authors: Olivi, Laura; Vandenbriele, Christophe; Gu, Yu-Mei; Salvi, Erika; Carpini, Simona Delli; Liu, Yan-Ping; Jacobs, Lotte; Jin, Yu; Thijs, Lutgarde; Citterio, Lorena; Cusi, Daniele; Verhamme, Peter; Staessen, Jan A.
• Is Part Of: Blood pressure. Volume 24:Number 1(2015)
• Page Start: 61
• Page End: 64
• Publication Date: 2015-02
• Subjects: Blood pressure -- Periodicals; Hypertension -- Periodicals; Hypertension -- Periodicals; Blood Pressure -- Periodicals; 612.14
• DOI: 10.3109/08037051.2014.986928
• Languages: English
• ISSNs: 0803-7051

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: Platelet endothelial aggregation receptor 1 <italic>(PEAR1</italic>) is a membrane protein involved in platelet contact-induced activation and sustained platelet aggregation. Experimental studies identified <italic>PEAR1</italic>, as a candidate gene that may be linked to the blood-pressure driven kidney injury in salt-sensitive Dahl rats. <italic>Aim</italic>: In a family-based European population study (mean age 39.7 years; 52.2% women), we searched for association of changes in blood pressure or incidence of hypertension with genetic variation in <italic>PEAR1. Methods:</italic> Among 1973 randomly recruited people, genotyped for <italic>PEAR1</italic>, we measured blood pressure at baseline and follow-up. <italic>Results</italic>: Median follow-up was 10.0 years. While accounting for family clusters and blood pressure at baseline and with adjustments applied for sex, age, body mass index, smoking and drinking, total cholesterol, and antihypertensive drug treatment, all associations of systolic and diastolic blood pressure changes with nine single nucleotide polymorphisms (SNPs) in <italic>PEAR1</italic> were all non-significant (<italic>p</italic> ≥ 0.059). With similar adjustments, the incidence of hypertension (397 cases among 1532 participants were normotensive at baseline [25.9%]) was not related to the SNPs in <italic>PEAR1</italic> (hazard ratios ≤ 1.09; <italic>p</italic> ≥ 0.09). <italic>Conclusion</italic>: Our study suggests that <italic>PEAR1</italic> is not a hypertension susceptibility gene in humans.</p> </abstract>