Short-Course Radiotherapy in Elderly Patients with Early Stage Non-Melanoma Skin Cancer: A Phase II Study. (7th February 2015)

• Record Type: Journal Article
• Authors: Ferro, Marica; Deodato, Francesco; Macchia, Gabriella; Gentileschi, Stefano; Cilla, Savino; Torre, Gabriella; Padula, Gilbert D. A.; Nuzzo, Marianna; Massaccesi, Mariangela; Valentini, Vincenzo; Morganti, Alessio G.
• Is Part Of: Cancer investigation. Volume 33:Number 2(2015)
• Page Start: 34
• Page End: 38
• Publication Date: 2015-02-07
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2014.998835
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Aim</italic>: <bold>To evaluate</bold> outcome <bold>of an accelerated</bold> radiotherapy (<bold>RT) regimen in elderly patients with</bold> an <bold>early</bold> stage non-melanoma skin cancer (<bold>NMSC)</bold>. <italic>Methods</italic>: Total RT dose was 30 Gy in 5 Gy fractions in six consecutive days. <italic>Results</italic>: <bold>Thirty-one patients were enrolled. Fourteen</bold> were aged ≥<bold>80 years</bold>. <bold>Acute skin</bold> and o<bold>bserved late toxicity were exclusively</bold> of <bold>grade 1</bold>. Thirty <bold>patients showed a complete response (median follow-up 30 months).</bold> Two-year <bold>actuarial local control was</bold> 93.2%. <bold>The cosmetic result</bold> was mostly <bold>judged</bold> as good or excellent. <italic>Conclusions</italic>: <bold>Short-course RT in elderly NMSC patients produces &gt;90% local control of disease.</bold></p> </abstract>