Hyperbaric oxygen for long-term complications of radiation cystitis. Issue 1 (4th November 2014)

• Record Type: Journal Article
• Authors: Ferreira, Carlos; Reis, Frederico; Correia, Tiago; Cardoso, André; Cerqueira, Manuel; Almeida, Martinho; Prisco, Rui; Camacho, Oscar
• Is Part Of: Journal of radiotherapy in practice. Volume 14:Issue 1(2014)
• Page Start: 18
• Page End: 26
• Publication Date: 2014-11-04
• Subjects: Radiotherapy -- Periodicals; 615.842005
• DOI: 10.1017/S1460396914000375
• Languages: English
• ISSNs: 1460-3969

Abstract

<abstract abstract-type="normal"> <title>Abstract</title> <sec id="abs1" sec-type="intro"> <title>Introduction</title> <p>Bladder complications may be seen in up to 12% of patients treated with pelvic irradiation. To report the long-term efficacy of hyperbaric oxygen therapy (HBOT) on radiation-induced cystitis.</p> </sec> <sec id="abs2" sec-type="methods"> <title>Methods</title> <p>We followed 70 patients diagnosed with radiation cystitis submitted to HBOT in our institution from 2007 to 2013. All patients answered a questionnaire documenting symptom severity pre-HBOT and at the end of the follow-up period using the Late Effects of Normal Tissues – Subjective, Objective, Management, Analytical (LENT-SOMA) scale. Our treatment protocol consisted of multiple sessions (median of 40) of 100% oxygen delivery in a multiplace hyperbaric chamber at 2·4 atm for 80 minutes.</p> </sec> <sec id="abs3" sec-type="results"> <title>Results</title> <p>With a median follow-up of 55·5 (4–85) months, the success rate after the follow-up period in terms of haematuria resolution or improvement was 91·4%. The mean score of each subjective variable of LENT-SOMA scale (dysuria, frequency, haematuria, incontinence) were significantly lower after the follow-up period (<italic>p</italic><0·05) with the exception of decreased stream (<italic>p</italic>=0·14). The sum of all subjective scores of LENT-SOMA scale was also significantly lower after the follow-up period (<italic>p</italic><0·05). No serious complications were observed.</p> </sec> <sec id="abs4" sec-type="conclusions"> <title>Conclusions</title> <p>Our results highlight the safety and long-term benefits of HBOT on haemorrhagic radiation cystitis and other distressful bladder symptoms.</p> </sec> </abstract>