A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). Issue 8 (10th October 2013)

• Record Type: Journal Article
• Authors: Shivappa, Nitin; Steck, Susan E; Hurley, Thomas G; Hussey, James R; Ma, Yunsheng; Ockene, Ira S; Tabung, Fred; Hébert, James R
• Is Part Of: Public health nutrition. Volume 17:Issue 8(2014)
• Page Start: 1825
• Page End: 1833
• Publication Date: 2013-10-10
• Subjects: Nutrition -- Periodicals; Nutrition policy -- Periodicals; Public health -- Periodicals; 613.2
• DOI: 10.1017/S1368980013002565
• Languages: English
• ISSNs: 1368-9800

Abstract

<abstract abstract-type="normal"> <title>Abstract</title> <sec id="abs1" sec-type="general"> <title>Objective</title> <p>To perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator.</p> </sec> <sec id="abs2" sec-type="general"> <title>Design</title> <p>Using data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i.e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (≤3 mg/l, >3 mg/l), while controlling for important potential confounders.</p> </sec> <sec id="abs3" sec-type="general"> <title>Setting</title> <p>Existing data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year.</p> </sec> <sec id="abs4" sec-type="subjects"> <title>Subjects</title> <p>Participants who had at least one hs-CRP measurement over her/his 1-year participation (<italic>n</italic> 495 for 24HR, <italic>n</italic> 559 for 7DDR).</p> </sec> <sec id="abs5" sec-type="results"> <title>Results</title> <p>Higher DII scores were associated with values of hs-CRP >3 mg/l (OR = 1·08; 95 % CI 1·01, 1·16, <italic>P</italic> = 0·035 for the 24HR; and OR = 1·10; 95 % CI 1·02, 1·19, <italic>P</italic> = 0·015 for the 7DDR).</p> </sec> <sec id="abs6" sec-type="conclusion"> <title>Conclusions</title> <p>The population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals' intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.</p> </sec> </abstract>