Splicing together sister chromatids. (29th September 2014)

• Record Type: Journal Article
• Authors: Valcárcel, Juan; Malumbres, Marcos
• Is Part Of: EMBO journal. Volume 33:Number 22(2014)
• Page Start: 2601
• Page End: 2603
• Publication Date: 2014-09-29
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201489988
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" xml:lang="en" id="embj201489988-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">Splicing of pre‐mRNAs is a necessary step for expression of the majority of genes in higher eukaryotes, and its regulation through alternative splice site selection shapes their proteomes. Defects in multiple splicing factors result in aberrant mitotic progression, although the molecular basis for this observation has remained elusive. Recent papers in <italic>The EMBO Journal</italic> and <italic>EMBO Reports</italic> reveal that expression of sororin, a critical regulator that stabilizes cohesin rings in sister chromatids, is exquisitely sensitive to defects in the splicing machinery, thus explaining the striking link between spliceosome function and chromosome segregation.</p> </abstract>