Membrane tension drives ligand‐independent integrin signaling. (17th September 2014)

• Record Type: Journal Article
• Authors: Böttcher, Ralph Thomas; Fässler, Reinhard
• Is Part Of: EMBO journal. Volume 33:Number 21(2014)
• Page Start: 2439
• Page End: 2441
• Publication Date: 2014-09-17
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201489886
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" id="embj201489886-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">Integrins anchor cells to the extracellular matrix (ECM) and control a multitude of essential cellular functions by activating a variety of signaling pathways. In this issue of <italic>The EMBO Journal</italic>, a study conducted by Ferraris and colleagues report that binding of urokinase‐type plasminogen activator receptor (uPAR) to vitronectin is sufficient to trigger ligand‐independent β1 and β3 integrin signaling. The coupling of uPAR and integrins occurs independent of lateral interaction between the two receptors, but relies on membrane tension (Ferraris <italic>et al</italic>, <xref ref-type="link" rid="embj201489886-bib-0001">2014</xref>).</p> </abstract>