Differences in survival for patients with metastatic colorectal cancer by lines of treatment received and stage at original diagnosis. Issue 2 (10th October 2014)

• Record Type: Journal Article
• Authors: Seal, B.; Chastek, B.; Kulakodlu, M.; Valluri, S.
• Is Part Of: International journal of clinical practice. Volume 69:Issue 2(2015)
• Page Start: 251
• Page End: 258
• Publication Date: 2014-10-10
• Subjects: Clinical medicine -- Periodicals; Medicine -- Periodicals; 610.5
• DOI: 10.1111/ijcp.12543
• Languages: English
• ISSNs: 1368-5031

Abstract

<abstract abstract-type="main" id="ijcp12543-abs-0001"> <title>Summary</title> <sec id="ijcp12543-sec-0001" sec-type="section"> <title>Objective</title> <p>Few published studies have examined survival rates for patients with metastatic colorectal cancer (mCRC) by number of lines of treatment received or stage at diagnosis. This study aims to evaluate survival and numbers of lines of treatment in USA mCRC managed care patients.</p> </sec> <sec id="ijcp12543-sec-0002" sec-type="section"> <title>Methods</title> <p>To evaluate the impact of chemotherapy/biological on survival of patients with mCRC, adults with a diagnosis of CRC between 1 January 2005 and 31 May 2010 were identified from the Oncology Management registry. Registry data included stage and diagnosis date. Patients with stage IV CRC at original diagnosis or development of metastasis were included. Linked healthcare claims from a large USA database were used to identify lines of treatment after metastasis and patient characteristics. The patient population was enrolled in a commercial health insurance programme, with 10% of patients > 65 years of age. Patients were categorised by lines of treatment received (0, 1, 2, 3+) and stage at original diagnosis (0–3, 4, unknown). Survival following metastasis was evaluated using Cox proportional hazards models controlling for lines of treatment, disease stage, and other patient characteristics.</p> </sec> <sec id="ijcp12543-sec-0003" sec-type="section"> <title>Results</title> <p>Study population included commercially insured adult patients, ≥ 18 years of age (<italic>n</italic> = 598, mean age 54, 56% male), 16% of which did not receive chemotherapy/biological therapy after becoming metastatic, and 33% received only 1 line of treatment. Average follow‐up was 653 days, and 19% of patients died during the study period. Mean unadjusted length of follow‐up was 516, 511, 627 and 930 days for patients who received 0, 1, 2 and 3+ lines of treatment, respectively. In the Cox proportional hazards model, geographical region was the only variable significantly associated with survival (p < 0.05).</p> </sec> <sec id="ijcp12543-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Lines of treatment received and stage at original diagnosis were not statistically significantly associated with survival after metastasis development.</p> </sec> </abstract>