The locus C11orf30 increases susceptibility to poly‐sensitization. Issue 3 (24th December 2014)

• Record Type: Journal Article
• Authors: Amaral, A. F. S.; Minelli, C.; Guerra, S.; Wjst, M.; Probst‐Hensch, N.; Pin, I.; Svanes, C.; Janson, C.; Heinrich, J.; Jarvis, D. L.
• Is Part Of: Allergy. Volume 70:Issue 3(2015:Mar.)
• Page Start: 328
• Page End: 333
• Publication Date: 2014-12-24
• Subjects: Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.12557
• Languages: English
• ISSNs: 0105-4538

Abstract

<abstract abstract-type="main" id="all12557-abs-0001"> <title>Abstract</title> <p>A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly‐sensitization is unknown. Using data from the large multicentre population‐based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly‐sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, <italic>C11orf30</italic>‐rs2155219, doubles the risk of poly‐sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80–4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34–3.95). The association of rs2155219 with higher levels of expression of <italic>C11orf30</italic>, which may be involved in transcription repression of interferon‐stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.</p> </abstract>