Treatment of elderly patients with acute myeloid leukemia with azacitidine results in fewer hospitalization days and infective complications but similar survival compared with intensive chemotherapy. Issue 1 (28th December 2014)

• Record Type: Journal Article
• Authors: Lao, Zhentang; Yiu, Richard; Wong, Gee Chuan; Ho, Aloysius
• Is Part Of: Asia-Pacific journal of clinical oncology. Volume 11:Issue 1(2015:Mar.)
• Page Start: 54
• Page End: 61
• Publication Date: 2014-12-28
• Subjects: Oncology -- Pacific Area -- Periodicals; Cancer -- Treatment -- Pacific Area -- Periodicals; Cancer -- Pacific Area -- Periodicals; Cancer -- Treatment -- Periodicals; 616.9940095
• DOI: 10.1111/ajco.12331
• Languages: English
• ISSNs: 1743-7555

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ajco12331-sec-0001" sec-type="section"> <title>Aims</title> <p>Azacitidine has been shown to prolong overall survival (OS) compared with best supportive care in elderly patients with acute myeloid leukemia (AML) with low blast counts but it is unknown if azacitidine has a similar efficacy in patients with blast counts of >30%. It is also unknown if azacitidine is comparable to intensive chemotherapy in terms of survival and morbidity.</p> </sec> <sec id="ajco12331-sec-0002" sec-type="section"> <title>Methods</title> <p>Differences between the outcomes of elderly AML patients who received intensive chemotherapy, azacitidine‐based therapy or best supportive care are studied in this retrospective review. Patients 60 years or older diagnosed with AML between January 2009 and June 2011 were included. Those who passed away within less than 2 weeks of diagnosis were excluded.</p> </sec> <sec id="ajco12331-sec-0003" sec-type="section"> <title>Results</title> <p>At a median follow‐up of 7.2 months (range: 0.5–26.4 months), estimated median OS for patients who received azacitidine‐based therapy was 9.8 months (range: 2.4–22.5 months) compared with 8.9 months (range: 0.9–26.4 months) for patients who received intensive chemotherapy (<italic>P</italic> = 0.89). Compared with azacitidine‐based therapy, intensive chemotherapy is associated with more inpatient days and episodes of febrile illness requiring inpatient stay or intravenous antibiotics.</p> </sec> <sec id="ajco12331-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Compared with intensive chemotherapy in elderly patients with AML, azacitidine‐based therapy is associated with similar median survival but lower number of hospitalization days and infective episodes.</p> </sec> </abstract>