Phase II study on hepatic arterial infusion chemotherapy using percutaneous catheter placement techniques for liver metastases from colorectal cancer (JFMC28 study). Issue 1 (12th January 2015)

• Record Type: Journal Article
• Authors: Arai, Yasuaki; Aoyama, Toru; Inaba, Yoshitaka; Okabe, Haruumi; Ihaya, Takashi; Kichikawa, Kimihiko; Ohashi, Yasuo; Sakamoto, Junichi; Oba, Koji; Saji, Shigetoyo
• Is Part Of: Asia-Pacific journal of clinical oncology. Volume 11:Issue 1(2015:Mar.)
• Page Start: 41
• Page End: 48
• Publication Date: 2015-01-12
• Subjects: Oncology -- Pacific Area -- Periodicals; Cancer -- Treatment -- Pacific Area -- Periodicals; Cancer -- Pacific Area -- Periodicals; Cancer -- Treatment -- Periodicals; 616.9940095
• DOI: 10.1111/ajco.12324
• Languages: English
• ISSNs: 1743-7555

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ajco12324-sec-0001" sec-type="section"> <title>Aim</title> <p>This prospective multicenter study aimed to evaluate the efficacy and adverse events of hepatic arterial infusion chemotherapy (HAIC) using percutaneous catheter placement techniques for liver metastases from colorectal cancer (CRC).</p> </sec> <sec id="ajco12324-sec-0002" sec-type="section"> <title>Methods</title> <p>We administered 5‐fluorouracil at 1000 mg/m<sup>2</sup> over 5 h via hepatic arterial infusion on a weekly schedule. The primary endpoint was the overall response rate (RR). The secondary endpoints were the overall survival (OS), progression‐free survival (PFS) and toxicities.</p> </sec> <sec id="ajco12324-sec-0003" sec-type="section"> <title>Results</title> <p>Between February 2000 and March 2002, seventy‐seven eligible patients were enrolled in this study. After a median of 26 treatment cycles, 4 patients achieved a complete response, 29 achieved a partial response, 28 had stable disease, 15 had progressive disease and the status of one patient was unknown. The overall RR was 42.9% and the disease control rate (DCR) was 79.2%. The median PFS and OS times were 203 and 560 days, respectively. The most common grade 3 or 4 hematological and non‐hematological toxicities were total bilirubin level elevation (10.4%) and gamma‐glutamyl transferase level elevation (10.4%). With regard to the relationship between the background factors and treatment outcomes, the DCR, RR, PFS and OS were different between patients with and without extrahepatic lesions (DCR: 86.5% <italic>vs</italic> 64%, RR: 46.2% <italic>vs</italic> 36.0%, PFS: 233 days <italic>vs</italic> 99 days, OS: 587 days <italic>vs</italic> 558 days).</p> </sec> <sec id="ajco12324-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The primary endpoint of this study was not met. HAIC using percutaneous catheter placement techniques did not improve the RR for liver metastasis from CRC.</p> </sec> </abstract>