Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Rasburicase Therapy in the Context of G6PD Deficiency Genotype. Issue 2 (2nd May 2014)

• Record Type: Journal Article
• Authors: Relling, M V; McDonagh, E M; Chang, T; Caudle, K E; McLeod, H L; Haidar, C E; Klein, T; Luzzatto, L
• Is Part Of: Clinical pharmacology & therapeutics. Volume 96:Issue 2(2014)
• Page Start: 169
• Page End: 174
• Publication Date: 2014-05-02
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1038/clpt.2014.97
• Languages: English
• ISSNs: 0009-9236

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is associated with development of acute hemolytic anemia (AHA) induced by a number of drugs. We provide guidance as to which <italic>G6PD</italic> genotypes are associated with G6PD deficiency in males and females. Rasburicase is contraindicated in G6PD‐deficient patients due to the risk of AHA and possibly methemoglobinemia. Unless preemptive genotyping has established a positive diagnosis of G6PD deficiency, quantitative enzyme assay remains the mainstay of screening prior to rasburicase use. The purpose of this article is to help interpret the results of clinical <italic>G6PD</italic> genotype tests so that they can guide the use of rasburicase. Detailed guidelines on other aspects of the use of rasburicase, including analyses of cost‐effectiveness, are beyond the scope of this document. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines are published and updated periodically on <ext-link ext-link-type="uri" xlink:href="https://www.pharmgkb.org/page/cpic" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.pharmgkb.org/page/cpic</ext-link> to reflect new developments in the field.</p> <p> <italic>Clinical Pharmacology & Therapeutics</italic> (2014); <bold>96</bold> 2, 169–174. doi:<ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">10.1038/clpt.2014.97</ext-link></p> </abstract>