Antipsychotics and Associated Risk of Out‐of‐Hospital Cardiac Arrest. Issue 4 (24th June 2014)

• Record Type: Journal Article
• Authors: Weeke, P; Jensen, A; Folke, F; Gislason, G H; Olesen, J B; Fosbøl, E L; Wissenberg, M; Lippert, F K; Christensen, E F; Nielsen, S L; Holm, E; Kanters, J K; Poulsen, H E; Køber, L; Torp‐Pedersen, C
• Is Part Of: Clinical pharmacology & therapeutics. Volume 96:Issue 4(2014)
• Page Start: 490
• Page End: 497
• Publication Date: 2014-06-24
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1038/clpt.2014.139
• Languages: English
• ISSNs: 0009-9236

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out–of–hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCAs in Denmark (2001–2010). The risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case–time–control models. In total, 2, 205 (7.6%) of 28, 947 OHCA patients received treatment with an antipsychotic drug at the time of the event. Overall, treatment with any antipsychotic drug was associated with OHCA (odds ratio (OR) = 1.53, 95% confidence interval (CI): 1.23–1.89), as was use with typical antipsychotics (OR = 1.66, CI: 1.27–2.17). By contrast, overall, atypical antipsychotic drug use was not (OR = 1.29, CI: 0.90–1.85). Two individual typical antipsychotic drugs, haloperidol (OR = 2.43, CI: 1.20–4.93) and levomepromazine (OR = 2.05, CI: 1.18–3.56), were associated with OHCA, as was one atypical antipsychotic drug, quetiapine (OR = 3.64, CI: 1.59–8.30).</p> <p> <italic>Clinical Pharmacology &amp; Therapeutics</italic> (2014); <bold>96</bold> 4, 490–497. doi:<ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">10.1038/clpt.2014.139</ext-link></p> </abstract>